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Individualized Risk Profile

Perturbation Dashboard

Each domain is scored against the individual's own L-44 baseline — not a population reference. This answers “how much did this person change?” rather than “are they normal?”

How to read this dashboard

These findings describe four individuals at one point in time. No finding should be generalized to spaceflight health broadly. Individual differences dominate the signal. Scores labeled “2× individual baseline” use derived thresholds, not clinical cutoffs.

Select a crew member

C001

Commander

C002

Pilot

C003

Medical Officer

C004

Mission Specialist

Biological domains

Select a crew member above to see their individual trajectory across each domain.

Immune Regulation

OSD-570 VDJ repertoire
PBMC snRNA-seq
OSD-575 cytokine panel

Inflammation

OSD-575 cardiovascular panel (CRP, haptoglobin, fibrinogen)
CBC WBC/neutrophil
TNFα/IL-6/IL-1β

Oxidative Stress

OSD-571 metabolomics (glutathione, oxidized lipids, acylcarnitines)
OSD-571 proteomics

DNA Damage Response

data-limited

OSD-571 bulk RNA-seq transcriptomic DDR signatures

Mitochondrial Function

OSD-571 metabolomics (TCA cycle, acylcarnitines)
OSD-571 proteomics